abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-associated invariant T (MAIT) cells are the predominant subset of MR1T cells express...

journal_title：Frontiers in immunology

authors： Swarbrick GM,Gela A,Cansler ME,Null MD,Duncan RB,Nemes E,Shey M,Nsereko M,Mayanja-Kizza H,Kiguli S,Koh J,Hanekom WA,Hatherill M,Lancioni C,Lewinsohn DM,Scriba TJ,Lewinsohn DA

更新日期：2020-09-16 00:00:00

abstract：:Newborns are at significantly increased risk of severe disease following infection with influenza virus. This is the collective result of their naïve status, altered immune responsiveness, and the lack of a vaccine that is effective in these individuals. Numerous studies have revealed impairments in both the innate an...

journal_title：Frontiers in immunology

authors： Alexander-Miller MA

更新日期：2020-09-16 00:00:00

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Neverthele...

journal_title：Frontiers in immunology

authors： Orbach R,Su X

更新日期：2020-09-11 00:00:00

abstract：:Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the scaffold and the prot...

journal_title：Frontiers in immunology

authors： Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

更新日期：2020-09-11 00:00:00

abstract：:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing t...

journal_title：Frontiers in immunology

authors： McCaughan GW,Bowen DG,Bertolino PJ

更新日期：2020-09-11 00:00:00

abstract：:Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved ...

journal_title：Frontiers in immunology

authors： Mosa AI

更新日期：2020-09-11 00:00:00

abstract：:Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host miRNAs that respond t...

journal_title：Frontiers in immunology

authors： Woldemariam NT,Agafonov O,Sindre H,Høyheim B,Houston RD,Robledo D,Bron JE,Andreassen R

更新日期：2020-09-11 00:00:00

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA)4 and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there is little information on CTLA4 and PD-1 expression levels and their clinical significance across diverse cancers. In this study, we addressed...

journal_title：Frontiers in immunology

authors： Liu JN,Kong XS,Huang T,Wang R,Li W,Chen QF

更新日期：2020-09-10 00:00:00

abstract：Background:The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods:This was a single ...

journal_title：Frontiers in immunology

authors： Spinella PC,Thomas KA,Turnbull IR,Fuchs A,Bochicchio K,Schuerer D,Reese S,Coleoglou Centeno AA,Horn CB,Baty J,Shea SM,Meledeo MA,Pusateri AE,Levy JH,Cap AP,Bochicchio GV,TAMPITI Investigators.

更新日期：2020-09-08 00:00:00

abstract：:Background: More than 50 different monogenic disorders have been identified as directly causing inflammatory bowel diseases, typically manifesting in the first years of life. We present the clinical course and immunological work-up of an adult patient who presented in adolescent years with an atypical gastrointestinal...

journal_title：Frontiers in immunology

authors： Vardi I,Chermesh I,Werner L,Barel O,Freund T,McCourt C,Fisher Y,Pinsker M,Javasky E,Weiss B,Rechavi G,Hagin D,Snapper SB,Somech R,Konnikova L,Shouval DS

更新日期：2020-09-04 00:00:00

abstract：:Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphati...

journal_title：Frontiers in immunology

authors： Soloff AC,Jones KE,Powers AA,Murthy P,Wang Y,Russell KL,Byrne-Steele M,Lund AW,Yuan JM,Monaco SE,Han J,Dhupar R,Lotze MT

更新日期：2020-09-04 00:00:00

abstract：:Increasing studies have highlighted the effects of the tumor immune micro-environment (TIM) on colon cancer (CC) tumorigenesis, prognosis, and metastasis. However, there is no reliable molecular marker that can effectively estimate the immune infiltration and predict the CC relapse risk. Here, we leveraged the gene ex...

journal_title：Frontiers in immunology

authors： Li X,Wen D,Li X,Yao C,Chong W,Chen H

更新日期：2020-09-03 00:00:00

abstract：:It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mouse models, a reduced secretion of cytokines has been observed. Still, ...

journal_title：Frontiers in immunology

authors： Spitzer P,Walter M,Göth C,Oberstein TJ,Linning P,Knölker HJ,Kornhuber J,Maler JM

更新日期：2020-09-03 00:00:00

abstract：:Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has ...

journal_title：Frontiers in immunology

authors： Davidov V,Jensen G,Mai S,Chen SH,Pan PY

更新日期：2020-09-02 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Richter's syndrome), ...

journal_title：Frontiers in immunology

authors： Märklin M,Fuchs AR,Tandler C,Heitmann JS,Salih HR,Kauer J,Quintanilla-Martinez L,Wirths S,Kopp HG,Müller MR

更新日期：2020-09-02 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and ...

journal_title：Frontiers in immunology

authors： Laabei M,Colineau L,Bettoni S,Maziarz K,Ermert D,Riesbeck K,Ram S,Blom AM

更新日期：2020-09-02 00:00:00

abstract：Background:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading worldwide. Measuring the prevention and control of the disease has become a matter requiring urgent focus. Objective:Based on coronavirus disease 2019 (COVID-19) clinical data from Wuhan, we conducted an in-depth analysis to...

journal_title：Frontiers in immunology

authors： Qun S,Wang Y,Chen J,Huang X,Guo H,Lu Z,Wang J,Zheng C,Ma Y,Zhu Y,Xia D,Wang Y,He H,Wang Y,Fei M,Yin Y,Zheng M,Xu Y,Ge W,Hu F,Zhou J

更新日期：2020-09-02 00:00:00

abstract：:The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

journal_title：Frontiers in immunology

authors： Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

更新日期：2020-09-02 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism. However, it is unknown whether serine modulates the macrophage function independent of one-carbon metabolism. Here, we find that s...

journal_title：Frontiers in immunology

authors： Chen S,Xia Y,He F,Fu J,Xin Z,Deng B,He L,Zhou X,Ren W

更新日期：2020-08-27 00:00:00

abstract：:The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined...

journal_title：Frontiers in immunology

authors： Yang L,Fu J,Zhou Y

更新日期：2020-08-27 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its inf...

journal_title：Frontiers in immunology

authors： Morath C,Döhler B,Kälble F,Pego da Silva L,Echterdiek F,Schwenger V,Živčić-Ćosić S,Katalinić N,Kuypers D,Benöhr P,Haubitz M,Ziemann M,Nitschke M,Emmerich F,Pisarski P,Karakizlis H,Weimer R,Ruhenstroth A,Scherer S,Tr

更新日期：2020-08-26 00:00:00

abstract：:Dendritic cells (DCs) are the guardians of the immune system since they are located in the majority of peripheral tissues. In addition, they are crucial for the induction of an effective immune response based on their unique capacity to stimulate naive T cells. During co-evolution, the human pathogen herpes simplex vi...

journal_title：Frontiers in immunology

authors： Birzer A,Krawczyk A,Draßner C,Kuhnt C,Mühl-Zürbes P,Heilingloh CS,Steinkasserer A,Popella L

更新日期：2020-08-26 00:00:00

abstract：:Trauma represents a major socioeconomic burden worldwide. After a severe injury, hemorrhagic shock (HS) as a frequent concomitant aspect is a central driver of systemic inflammation and organ damage. The kidney is often strongly affected by traumatic-HS, and acute kidney injury (AKI) poses the patient at great risk fo...

journal_title：Frontiers in immunology

authors： Halbgebauer R,Karasu E,Braun CK,Palmer A,Braumüller S,Schultze A,Schäfer F,Bückle S,Eigner A,Wachter U,Radermacher P,Resuello RRG,Tuplano JV,Nilsson Ekdahl K,Nilsson B,Armacki M,Kleger A,Seufferlein T,Kalbitz M,Gebh

更新日期：2020-08-26 00:00:00

abstract：:Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at the maternal-fetal interface, especially during HIV infection, is still poorly known. In this study, we investigated the relationship between pregnancy and innate mechanisms associated with HIV immunity by e...

journal_title：Frontiers in immunology

authors： Pereira NZ,Branco ACCC,Manfrere KCG,de Lima JF,Yoshikawa FSY,Milanez HMBPM,Pereira NV,Sotto MN,Duarte AJDS,Sato MN

更新日期：2020-08-25 00:00:00

abstract：:Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

journal_title：Frontiers in immunology

authors： Petre B

更新日期：2020-08-21 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：:One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-a...

journal_title：Frontiers in immunology

authors： Kaipe H,Raffetseder J,Ernerudh J,Solders M,Tiblad E

更新日期：2020-08-19 00:00:00

abstract：:We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...

journal_title：Frontiers in immunology

authors： Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

更新日期：2020-08-18 00:00:00

abstract：:Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Upon binding to CD38-expressing MM cells, isatuximab is thought to induce tumor cell killing via fragment crystallizable (...

journal_title：Frontiers in immunology

authors： Zhu C,Song Z,Wang A,Srinivasan S,Yang G,Greco R,Theilhaber J,Shehu E,Wu L,Yang ZY,Passe-Coutrin W,Fournier A,Tai YT,Anderson KC,Wiederschain D,Bahjat K,Adrián FJ,Chiron M

更新日期：2020-08-14 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of people living with HIV-2 (PLWHIV-2), compared to blood bank heal...

journal_title：Frontiers in immunology

authors： Iannetta M,Isnard S,Manuzak J,Guillerme JB,Notin M,Bailly K,Andrieu M,Amraoui S,Vimeux L,Figueiredo S,Charmeteau-de Muylder B,Vaton L,Hatton EX,Samri A,Autran B,Thiébaut R,Chaghil N,Glohi D,Charpentier C,Descamps D

更新日期：2020-08-13 00:00:00